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They also have reduced subcutaneous fats (even though whole fat as measured as a proportion of body weight is increased), leading to a decrease in thermal insulation. Reflex vasoconstriction and vasodilation are impaired because of diminished sympathetic output and reduced vascular responsiveness. Using a mouse model, EspinosaMedina and colleagues demonstrated that the genetic signature of the sacral outflow tract neurons was better characterized as being of sympathetic origin, quite than parasympathetic. There is anatomic evidence that both thoracic and sacral preganglionic cell types occupy websites in the mediolateral area of the spinal twine and exit the spinal twine from a ventral place (compared with the dorsal exit sites of preganglionic parasympathetics of the cranial nerves). The advanced neurotransmitter phenotypes and pharmacologic responses of the sacral section of the spinal twine additionally seem to be primarily of sympathetic origin. The distribution of parasympathetic ganglia close to effector organs facilitates the extra targeted rest-and-digest capabilities of the parasympathetic system. This well-known description led to an improved taxonomy of adrenoreceptors that continues to be used at present. Reduction in halothane anesthetic requirement by clonidine, an -adrenergic agonist. The understanding that the autonomic response to surgical procedure could be modified by 2 agonists working in the spinal wire and within the mind additional contributed to the concept of "balanced anesthesia. Long-held anatomic charts depicting sympathetic and parasympathetic divisions of the autonomic nervous system are altering. The importance of thermoregulation and the consequences of anesthetic agents on the autonomic responses governing control of temperature are reviewed. The perform of nicotinic receptors in the brain, and their results on the autonomic nervous system by way of their ganglionic motion, receive a crucial evaluation on this paper. Comparison of the incidence of issues at induction and emergence in infants receiving oral atropine vs no premedication. Neuroendocrine response and coronary heart fee variability: a comparison of whole intravenous versus balanced anesthesia. Halothane anesthesia attenuates cardiopulmonary baroreflex control of peripheral resistance in people. Does subanesthetic isoflurane affect the ventilator response to acute isocapnic hypoxia in wholesome volunteers Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors. Simulation of hemodynamic responses to the Valsalva maneuver: an integrative computational model of the cardiovascular system and the autonomic nervous system. Sinus arrest induced by trivial nasal stimulation during alfentanil-nitrous oxide anesthesia. The yin and yang of cardiac autonomic management: vago sympathetic interactions revisited. Reduction in halothane anesthetic requirement by clonidine an -adrenergic agonist. Dexmedetomidine produces a hypnoticanesthetic action in rats by way of activation of central 2 adrenoreceptors. The measurement of neurovegatative exercise throughout anesthesia and surgical procedure in swine: an evaluation of various techniques. Autonomic nervous system state: the impact of common anaesthesia and bilateral tonsillectomy after unilateral infiltration of lidocaine. Effect of fentanyl on heart price variability during spontaneous and paced breathing in healthy volunteers. The influence of xenon on regulation of the autonomic nervous system in patents at high threat of periperative cardiac complications. Cardiac sympathovagal steadiness and peripheral sympathetic vasoconstriction: epidural versus common anesthesia. Heart price variability: a diagnostic and prognostic tool in anesthesia and intensive care. Pulsatile signaling and cardiovascular aging: features and regulation of natriuretic peptide signaling. Peripheral mechanisms of thermoregulatory management of skin blood flow in aged people. Autonomic "tone" maintains cardiac muscle, visceral organs, and vascular smooth muscle in a state of intermediate operate. From this state, rapid will increase or decreases in autonomic outflow can adjust blood move and organ activity in response to the surroundings.

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Patients can be given 12 mg half-hour to 5 hours earlier than surgery, adopted by 12 mg twice a day for as a lot as 7 days after surgery (maximum of 15 doses). An easy-to-remember guideline is that one antiemetic intervention is beneficial for each risk issue current. An overall strategy of minimizing opioids in favor of regional anesthesia and adjuvant nonopioid medications additionally reduces the chance the patient will expertise bowel dysfunction, nausea, and vomiting postoperatively. Numerous research have demonstrated improved outcomes when multiple lessons of antiemetics are used collectively as prophylaxis. One instance is a examine of chemotherapy-naive sufferers who have been pretreated with antiemetic therapy comprising palonosetron (0. Prevalence of the first endpoint in the course of the acute part, delayed part, and general was 100 percent, ninety one. There was no distinction within the incidence of nausea or want for rescue treatment between the research teams. This fixed-dose antiemetic combination presents improved prophylaxis from single-dose remedy. Although there are greater than 300 acupuncture points, one point that has been proven to be efficacious is the P6 point (the sixth level along the pericardial meridian). It may be located at 2 inches proximal to the palmar side of the wrist, between the flexor carpi radialis and palmaris longus tendons. Stimulation of the P6 acupuncture point has proven efficacy for prevention and therapy of nausea and vomiting within the perioperative interval. A Cochrane evaluate summarizing fifty nine trials with 7667 participants drew the following conclusions. A examine of ninety four sufferers undergoing cesarean part with spinal anesthesia were randomly assigned to receive transcutaneous accupoint electrical stimulation at the P6 point versus a sham location in hope of relieving both intraoperative and postoperative nausea and vomiting. Upon injection, fosaprepitant is rapidly converted to aprepitant and due to this fact has the identical mechanism of motion as aprepitant. Rolapitant seems to have a number of advantages over aprepitant, together with a long half-life of 180 hours. In addition, rolapitant is presently available only in an oral formulation and therefore must be administered preoperatively. The main endpoint was no retching or vomiting in the 24-hr postoperative period and no use of rescue antiemetics. There was no clinically significant difference within the safety profile of the research drug compared with the placebo. However, a examine in 2170 ambulatory sufferers in the United States discovered that the incidence of nausea and vomiting after discharge from the hospital was 37%, even after intraoperative prophylaxis with ondansetron or dexamethasone. However, further studies are required to examine absolutely the and relative worth of these and other antiemetics in the postdischarge setting. Extrapyramidal symptoms associated with the 25-mg dose affect lower than 1% of patients, however like different D2 antagonists, arrhythmias have been described. Most doseresponse research suggest that four mg is the minimally efficient dose with equal efficacy as 4 mg ondansetron and 1. An oral dose of 40 mg aprepitant reduces nausea by about 30% and vomiting by greater than 50%. It is thus significantly useful for surgical procedures in which postoperative vomiting may affect the success of the surgical procedure. A large multicenter trial of greater than 5000 patients demonstrating that the relative risk discount for 3 generally used antiemetic interventions are all in the vary of 25%, that efficacy is unbiased of affected person threat, and that antiemetic drugs of various classes act independently of one another. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from crossvalidations between two centers. Some interindividual variations in response to prophylaxis might therefore be as a outcome of genetic variations among patients. The individual relative threat versus placebo for all effective antiemetics ranged between 0.

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This article will talk about every of these drug classes intimately with an emphasis on the evidence that helps their utility in the perioperative and pain management setting. Careful consideration may also be given to some of the perioperative controversies of sure brokers; for example, the issues of surgical hemostasis and bone therapeutic with nonsteroidal anti-inflammatories. Paramount among these suggestions is the function of nonopioid analgesics in treating chronic ache, as evidenced by the first of 12 guidelines: Nonpharmacologic therapy and nonopioid pharmacologic therapy are most popular for chronic ache. If opioids are used, they should be mixed with nonpharmacologic therapy and nonopioid pharmacologic remedy, as acceptable. An further section discusses rising developments of various medication with potential utility within the perioperative and continual ache inhabitants. Mechanism Prostaglandins are lipid-based compounds derived enzymatically from fatty acids that have essential physiologic features, including the mediation of the inflammatory response, the transduction of ache alerts, and a central pyretic effect. In the late 18th century, Stone isolated salicylic acid from willow, myrtle, and a number of different crops. However, it was not until early within the 20th century that Hoffmann, a chemist with Bayer Pharmaceuticals, discovered acetylsalicylic acid and marketed aspirin for fever, ache, and inflammation. It was not until later in the 20th century that aspirin turned the generic name for this compound. Aspirin continues to be an necessary drug, however now extra for its antiplatelet activity than for its original indications. Since then several dozen agents have been launched within the United States and elsewhere, competing for a profitable commercial market. Over time, some of these agents have been withdrawn because of main toxicities, together with hepatotoxicity, nephrotoxicity, and blood dyscrasias. The current voluntary withdrawal of the blockbuster drug rofecoxib (Vioxx) generated appreciable controversy and media protection amid issues of elevated cardiovascular risk. Renal excretion of unmetabolized drug is way much less essential, accounting for less than 10% of the administered dose. Parenteral administration is advantageous in renal colic because of its extra speedy onset than with oral administration, nevertheless it has demonstrated no obvious benefit over oral administration for another indication. A retrospective evaluation of 288 patients who underwent instrumented spinal fusion from L4 to the sacrum demonstrated a five times larger nonunion price when ketorolac was used within the immediate postoperative interval. This constellation of physiologic derangements results in a spectrum of gastrointestinal issues, ranging from mild gastritis to peptic ulceration with perforation. Consequently, inhibition of platelet activation resolves after many of the drug is eradicated. For instance, a single 300- to 900-mg dose of ibuprofen can inhibit platelet aggregation for two hours after administration, and the effect is essentially dissipated by 24 hours. These effects happen more usually in sufferers with underlying renal illness and in those with intravascular quantity depletion. It is a analysis of exclusion after ruling out an infectious reason for the meningeal irritation. The excessive diploma of serum protein binding increases interplay risk with different extremely protein bound medication. Diclofenac has been the agent most implicated with hepatic dysfunction and should be avoided in patients with liver disease. Gastrointestinal bleeding and operative website bleeding have additionally been reported and are largely related to advanced patient age, duration of remedy beyond 5 days, and higher dosing regimens. The ketorolac product labeling now advises the next intravenous dosing protocol: for a single dose, 30 mg intravenously or 15 mg if patient age is bigger than sixty five 12 months or physique weight less than 50 kg; for multiple dosing, sufferers must be commenced on 30 mg each 6 hours, not to exceed 120 mg in a 24-hour interval; in those older than 65 years or weighing less than 50 kg, the dosing must be 15 mg each 6 hours, not to exceed 60 mg in 24 hours. Consequently, meloxicam might have a better gastrointestinal tolerability profile in contrast with nonselective agents and can be considered if celecoxib is unavailable or contraindicated. Time to measurable impact is about half-hour, with a peak impact noted at 1 to 2 hours and a length of motion of 4 to 6 hours. In the management of postoperative pain, ketorolac has confirmed very helpful, with an opioid-sparing impact and efficacy just like morphine within the treatment of moderate pain. Acetaminophen is a para-aminophenol by-product with analgesic and antipyretic properties just like aspirin. The very useful antipyretic impact is believed to be a direct impact on the hypothalamic heat-regulating centers by way of inhibiting action of endogenous pyrogens.

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Postoperative hypothermia in adults: relationship of age, anesthesia, and shivering to rewarming. Thermal control of blood flow through capillaries and arteriovenous anastomoses in pores and skin of sheep. Augmented thermic impact of amino acids under common anaesthesia occurs predominantly in extrasplanchnic tissues. Thermoregulatory vasoconstriction throughout isoflurane anesthesia minimally decreases warmth loss. Skin Arteriovenous Anastomoses, Their Control and Role in Thermoregulation, Cardiovascular Shunts: Phylogenetic, Ontogenetic and Clinical Aspects. Leg heat content material continues to lower during the core temperature plateau in people. Alfentanil barely increases the sweating threshold and markedly reduces the vasoconstriction and shivering thresholds. Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia. Preanesthetic skin-surface warming reduces redistribution hypothermia caused by epidural block. Epidural anesthesia increases obvious leg temperature and reduces the shivering threshold. Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. High thoracic segmental epidural anesthesia diminishes sympathetic outflow to the legs, despite restriction of sensory blockade to the upper thorax. Duration of cardiopulmonary bypass and its relationship to endotoxemia, systemic irritation and acute section response. Effect of peroperative normothermia on postoperative protein metabolism in aged patients undergoing hip arthroplasty. Epidural anesthesia impairs each central and peripheral thermoregulatory management during general anesthesia. Time course of sympathetic blockade during epidural anesthesia: laser doppler flowmetry studies of regional pores and skin perfusion. Mild intraoperative hypothermia increases period of motion and restoration time of vecuronium. Protection from cerebral ischemia by mind cooling with out reduced lactate accumulation in dogs. Safety of deliberate intraoperative and postoperative hypothermia for sufferers present process coronary artery surgery: a randomized trial. Observations within the postpartum restoration room after varied local anesthetic techniques. Effect of meperidine on oxygen consumption, carbon dioxide production, and respiratory gas trade in postanesthesia shivering. Postoperative hemodynamic and thermoregulatory penalties of intraoperative core hypothermia. Hypothermia and blood coagulation: dissociation between enzyme exercise and clotting issue levels. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. The impact of O2 pressure on microbicidal operate of leukocytes in wound and in vitro. Effect of temperature on the chemotaxis, phagocytic engulfment, digestion and O2 consumption of human polymorphonuclear leukocytes. Mild hypothermia during halothane-induced anesthesia decreases resistance to Staphylococcus aureus dermal infection in Guinea pigs. Comparison of the impact of bacterial inoculation in musculocutaneous and random-pattern flaps. Forced-air warming maintains intraoperative normothermia better than circulating-water mattresses. Effect of prewarming on post-induction core temperature and the incidence of inadvertent perioperative hypothermia in sufferers undergoing common anaesthesia. A third of patients undergoing surgical procedure continue to undergo from moderate to severe pain, leading to private struggling, protracted recovery including persistent ache after surgery, delayed hospital discharge, and elevated morbidity and mortality.

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Biosynthesis of lipophilic hormones and signaling molecules, together with: � Steroidhormone � Prostaglandins,Thromboxane,Eicosanoids � Bileandfattyacids � Retinoids � VitaminDderivatives � Porphyrins 2. This is believed to be an evolutionary defensive mechanism to toxin publicity by growing the capability to degrade the offending substance. For prodrugs and substances with energetic metabolites, however, enzyme induction can confer the risk of exaggerated drug results and potential hurt. Cytochrome P450 enzymes are liable for the overwhelming majority of biotransformation reactions for medicine presently used at present. Mammalian flavin-containing monooxygenases: structure/ perform, genetic polymorphisms and position in drug metabolism. These enzymes are critical to each homeostatic and xenobiotic metabolic pathways and are concerned in the biotransformation of aminergic neurotransmitters (such as catecholamines, histamine, and serotonin) in addition to toxins and carcinogens in meals and the environment. Each isoenzyme could be distinguished by sure substrate specificities and anatomic distribution (Table 4. In human physiology, esterases are distributed in the liver, erythrocytes, plasma, and the gastrointestinal tract. Proteases are specialised esterases and are concerned within the activation of proenzymes such as these secreted by the pancreas. Cholinesterases are serine hydrolases with particular relevance to the follow of anesthesiology. Discussion of pseudocholinesterase deficiency continues later in this chapter (also see Chapter 21). Functionally, transferases connect water-soluble sugars, amino acids, or salts to their substrates. The present understanding is that in these with the slow-acetylator phenotype, the father or mother drug accumulates and is diverted to oxidative metabolic pathways. This produces reactive intermediaries, haptens, and carcinogens at levels that would be a lot decrease within the intermediate- and fast-acetylator counterparts. This mechanism has been attributed to not solely the event of drug-induced autoimmune disorders similar to those seen with hydralazine and sulfonamides, but in addition the pathogenesis of bladder, breast, and colorectal cancer with persistent publicity to environmental carcinogens17 (Table four. The soluble kind is highly concentrated within the liver, whereas the membrane-bound kind is predominantly discovered within the central nervous system and the chromaffin cells of the adrenal glands. It is amongst the major metabolic pathways of catecholamines and associated compounds such as levodopa and -methyldopa. Deciphering the traditional and sophisticated evolutionary history of human arylamine N-acetyltransferase genes. They are especially essential in oncologic pharmacogenomics as they determine the uptake and efficacy of chemotherapeutics. It is positioned in the apical membranes of many epithelial cell sorts, including these of the gastrointestinal tract and mind and cerebrospinal fluid capillary endothelium. They additionally likely contribute to sustaining the integrity of the blood-brain barrier. This efflux transporter has a broad specificity and extrudes all kinds of substrates from cells, together with opioids, -blockers, calcium channel blockers, dexamethasone, ondansetron, digoxin and tricyclic antidepressants, as nicely as endogenous compounds similar to conjugated bilirubin. Similarly, many inducers and inhibitors of P-gp exist and may alter their function. For example, loperamide is a substrate for P-gp and is generally excluded from the enterocyte, which localizes its effect within the gastrointestinal tract. When coadministered with the P-gp inhibitors, the central results of loperamide, similar to sedation and respiratory despair, can occur. These are genetically and structurally heterogeneous buildings which are united by their function as uptake (and often bidirectional) transporters. Drug-drug interactions are greatest described for orally administered drugs, and people with a renal website of action or excretion such as diuretics and antihypertensives. One of the challenges in learning the consequences of drug transporter variants in vivo is the overlapping substrate vary of transporters and downstream metabolic enzymes.

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Conivaptan is a twin antagonist of V1a and V2 receptors used for euvolemic or hypervolemic hyponatremia. The condition can exist in a number of types categorized in phrases of the adequacy of intravascular quantity. This could be behavioral or, rarely, secondary to damage to the hypothalamic thirst facilities. Hypernatremia with regular volume standing may be divided into causes stemming from extrarenal water losses and renal water losses. Although uncommon, extrarenal lack of free water sufficient to produce hypernatremia may result from excessive insensible fluid loss corresponding to with prolonged hyperventilation. Hypernatremia produces neurologic signs (including stupor, coma, and seizures), hypovolemia, renal insufficiency (occasionally progressing to renal failure), and decreased urinary concentrating capability. The scientific penalties of hypernatremia are most severe at the extremes of age and when hypernatremia develops abruptly. Geriatric patients are at elevated danger of hypernatremia because of decreased renal concentrating capability and thirst. Polyuria may cause bladder distention, hydronephrosis, and permanent renal damage. However, bigger accidental increases in plasma Na+ have produced extreme consequences in youngsters. In experimental animals, acute severe hypernatremia (acute enhance from 146 to 170 mM) caused neuronal damage at 24 hours, suggestive of early osmotic demyelination. In many sufferers, preceding the development of hypernatremia, an elevated quantity of hypotonic urine suggests an abnormality in water balance. Although unusual as a cause of hypernatremia, isolated Na+ gain often happens in sufferers who receive massive quantities of Na+, similar to therapy of metabolic acidosis with 8. Measurement of urinary Na+ and osmolality may help differentiate the varied causes. Treatment of hypernatremia produced by water loss consists of repletion of water and correction of related deficits in total body Na+ and other electrolytes (Table 42. Common errors in treating hypernatremia embody excessively fast correction, failure to recognize the magnitude of the water deficit, and failure to account for ongoing upkeep requirements and continued fluid losses. In the occasional sodium-overloaded patient, Na+ excretion can be accelerated using loop diuretics or dialysis. It is less likely than vasopressin to produce vasoconstriction and stomach cramping. Intracellular K+ focus (K+) is often 150 mM, whereas the extracellular focus is just 3. The ratio of intracellular to extracellular K+ contributes to the resting potential distinction throughout cell membranes and subsequently to the integrity of cardiac and neuromuscular transmission. Extracellular K+ is determined by catecholamines, the reninangiotensin-aldosterone system, glucose, and insulin, in addition to direct release from exercising or injured muscle. Freely filtered on the glomerulus, most K+ excretion is urinary with some fecal elimination. Most filtered K+ is reabsorbed; excretion is usually approximately equal to consumption. Excretion of K+ ions is a operate of open K+ channels and the electrical driving pressure within the cortical collecting duct. Potassium secretion into the distal convoluted tubules and cortical amassing ducts is increased by hyperkalemia, aldosterone, alkalemia, increased supply of Na+ to the distal tubule and amassing duct, excessive urinary move rates, and the presence in luminal fluid of non-reabsorbable anions similar to carbenicillin, phosphates, and sulfates. As Na+ reabsorption will increase, the electrical driving pressure opposing reabsorption of K+ is increased. Aldosterone increases Na+ reabsorption by inducing opening of the epithelial Na+ channel40; potassium-sparing diuretics (amiloride and triamterene) and trimethroprim block the epithelial Na+ channel, thereby rising K+ reabsorption. In uncomplicated hypokalemia, the K+ deficit exceeds 300 mEq if plasma K+ is lower than 3.

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A response floor evaluation of propofol-remifentanil pharmacodynamic interplay in volunteers. Additivity was additionally proven for the bispectral index and other processed electroencephalogram indices similar to spectral entropy and response entropy, each in volunteer research and in the clinical setting. Nitrous oxide 67% decreases propofol requirements by 25% to 35% for the endpoint of surgical incision. The optimum dose ratios to present 95% chance of no motion to surgical stimulus with earliest wakeup times were propofol 3. The estimated time to 50% of patients being awake is 12 minutes for propofol-fentanyl and 6 minutes for propofol-remifentanil. The rapid offset of remifentanil compared with fentanyl means a better ratio of opioid to propofol ends in earlier wake-up times. Data are only displayed for a 1-hour infusion, with the differences smaller after temporary infusions and greater with prolonged infusions. The triple mixture of propofol, alfentanil, and midazolam has been studied for an endpoint of hypnosis. An exploration of remifentanil-propofol combos that result in loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of insupportable ventilatory despair. Midazolam is usually used to suppress emergence phenomena associated to ketamine and may additionally be utilized in combination for sedation or induction of anesthesia. Midazolam has an infraadditive impact on ketamine hypnosis and no impact on the ketamine dose required to suppress motion to a noxious stimulus. Recently response surface methodology was used to quantify synergy for rocuronium- and cisatracurium-induced muscle rest using train-of-four as the effect sign. The models contain changes for age, weight, peak, and intercourse and Real-time displays of predicted anesthetic drug results. The top display screen exhibits the interaction between propofol and sevoflurane in a patient induced with propofol for endpoints of sedation and analgesia. Notice the gap in our information quickly after induction, because the three-drug interaction among propofol, remifentanil, and sevoflurane has not been studied. The line on the isobologram reveals the effect course the affected person has taken, including a prediction of the longer term impact course given the present dosage. The calculations are accomplished in real time with changes in dosage continuously incorporated into the mannequin to predict likely effects. These prediction modules are intended to deliver the detailed data about anesthetic drug habits present in textbooks and the modeling literature to the clinical area by applying the fashions in actual time in a user-friendly display. Such data can be utilized to information a more correct titration of unstable and opioid dose. The inclusion of probabilities of movement and time to waking would possibly appear overly detailed, but they provide a more accurate appraisal of the sedative results of the medication given and their doubtless time course than was previously out there. It has been shown that isoflurane could be substituted for sevoflurane and fentanyl for remifentanil without lack of fidelity of the model, offering additional proof that phenylpiperidine-based opioids behave equally and can be used interchangeably. Pharmacodynamic-Based Target Control and Closed-loop Infusions Pharmacodynamic model, target-controlled infusion of propofol and remifentanil has been studied in trials experimentally utilizing a response floor mannequin to control the concentrations of the two medication to produce a predicted level of impact (bispectral index) quite than a predicted blood concentration. Analogous to this, a twin closed-loop controller that achieves the identical goal by titrating propofol and remifentanil in response to both bispectral index and arterial stress targets. Study of the pharmacology of widespread combos of medicine has tremendously increased our data of clinical anesthetic pharmacology. The combination of propofol with a unstable anesthetic corresponding to sevoflurane is additive. Pharmacodynamic interaction between propofol and remifentanil relating to hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy. There is an analysis of the likely implications for mechanisms of drug interaction. The authentic article describing the idea of balanced anesthesia and its benefits. The first research of volatile anestheticopioid interaction that used response floor analysis.


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